Ithimba elihlanganyelwe labacwaningi abavela e-Harvard Medical School (HMS) kanye ne-MIT General Hospital lithi lizuze ukulungiswa kokukhishwa kwelaser ye-microdisk lisebenzisa indlela yokunamathisela ye-PEC, okwenza umthombo omusha we-nanophotonics ne-biomedicine “uthembise.”
(Okukhiphayo kwe-laser microdisk kungalungiswa ngendlela ye-PEC etching)
Emasimini kai-nanophotonicskanye ne-biomedicine, i-microdiskama-lasernamalaser e-nanodisk asethembisayoimithombo yokukhanyakanye nama-probes. Kuzinhlelo zokusebenza ezimbalwa ezifana nokuxhumana kwe-on-chip photonic, i-on-chip bioimaging, inzwa ye-biochemical, kanye nokucubungula ulwazi lwe-quantum photon, zidinga ukuzuza okukhiphayo nge-laser ekunqumeni ubude be-wavelength kanye nokunemba kwebhendi encane kakhulu. Kodwa-ke, kuseyinselele ukwenza i-microdisk kanye namalaser e-nanodisk alobu bude beza obunembile ngezinga elikhulu. Izinqubo zamanje ze-nanofabrication zethula ukungahleleki kobubanzi bediski, okwenza kube nzima ukuthola ubude beza obumisiwe ekucutshungulweni kwesisindo se-laser nokukhiqizwa.Manje, ithimba labacwaningi abavela e-Harvard Medical School kanye nase-Massachusetts General Hospital's Wellman Center forImithi ye-Optoelectronicusungule indlela yokubhala ye-optochemical (PEC) emisha esiza ukushuna ngokunembile ubude begagasi be-laser belaser ye-microdisk ngokunemba kwe-subnanometer. Umsebenzi ushicilelwe kujenali ethi Advanced Photonics.
I-Photochemical etching
Ngokwemibiko, indlela entsha yeqembu inika amandla ukwakhiwa kwama-laser e-micro-disk kanye ne-nanodisk laser arrays enobude obunembile, obunqunywe kusengaphambili bokuphuma kwamaza. Isihluthulelo salokhu kuphumelela ukusetshenziswa kwe-PEC etching, ehlinzeka ngendlela ephumelelayo nengakalayo yokushuna kahle ubude begagasi be-laser microdisc. Kule miphumela engenhla, ithimba lithole ngempumelelo i-indium Gallium arsenide phosphating microdisks embozwe nge-silica esakhiweni sekholomu ye-indium phosphide. Babe sebeshuna ubude beza be-laser balawa ma-microdisk ngokuqondile enanini elinqunyiwe ngokwenza i-photochemical etching kusixazululo esihlanjululwe se-sulfuric acid.
Baphinde baphenya izindlela kanye nokuguquguquka kwe-etchings ethize ye-photochemical (PEC). Ekugcineni, badlulisela i-wavelength-tuned microdisk array ku-polydimethylsiloxane substrate ukuze kukhiqizwe izinhlayiya ze-laser ezizimele, ezihlukanisiwe ezinobude obuhlukahlukene be-laser. I-microdisk ewumphumela ibonisa i-ultra-wideband bandwidth yokukhishwa kwe-laser, nelaserkukholomu engaphansi kuka-0.6 nm kanye nezinhlayiyana ezingazodwa zingaphansi kuka-1.5 nm.
Ukuvula umnyango wezinhlelo zokusebenza ze-biomedical
Lo mphumela uvula umnyango kuma-nanophotonics amaningi amasha kanye nezicelo ze-biomedical. Isibonelo, ama-laser e-microdisk azimele angasebenza njengamabhakhodi e-physico-optical amasampula ebhayoloji ahlukahlukene, anikeze amandla ukulebula kwezinhlobo ezithile zamaseli nokukhomba ama-molecule athile ekuhlaziyeni okuningi. njengama-organic fluorophores, amachashazi e-quantum, kanye nobuhlalu be-fluorescent, anobubanzi obukhiphayo bomugqa. Ngakho, izinhlobo ezimbalwa zamaseli kuphela ezingalebula ngesikhathi esisodwa. Ngokuphambene, ukuphuma kokukhanya kwebhendi emincane kakhulu ye-microdisk laser kuzokwazi ukuhlonza izinhlobo eziningi zamaseli ngesikhathi esisodwa.
Ithimba lihlole futhi labonisa ngempumelelo izinhlayiya ze-laser microdisk ezishunwe ngokunembile njengama-biomarker, lizisebenzisa ukulebula amaseli e-epithelial webele ajwayelekile e-MCF10A. Ngokukhipha kwawo i-ultra-wideband, lawa ma-lasers angase akwazi ukuguqula i-biosensing, esebenzisa amasu afakazelwe we-biomedical kanye ne-optical njenge-imaging ye-cytodynamic, i-flow cytometry, nokuhlaziywa kwe-multi-omics. Ubuchwepheshe obusekelwe ku-PEC etching buphawula intuthuko enkulu kuma-laser microdisk. Ukuqina kwendlela, kanye nokunemba kwayo kwe-subnanometer, kuvula amathuba amasha okusetshenziswa kwe-lasers ku-nanophotonics namadivayisi we-biomedical, kanye namabhakhodi ezibalo zamaseli athile nama-molecule okuhlaziya.
Isikhathi sokuthumela: Jan-29-2024