Ithimba elihlangene locwaningo elivela eHarvard Medical School (HMS) kanye ne-MIT General Hospital lithi selifinyelele ekulungiseni umkhiqizo we-microdisk laser besebenzisa indlela ye-PEC etching, okwenza umthombo omusha we-nanophotonics kanye ne-biomedicine "ube yimpumelelo."
(Umphumela we-laser ye-microdisk ungalungiswa ngendlela ye-PEC etching)
Emasimini e-i-nanophotonicskanye ne-biomedicine, i-microdiskama-laserfuthi ama-laser e-nanodisk asethembisaimithombo yokukhanyakanye nama-probe. Ezinhlelweni eziningana ezifana nokuxhumana kwe-photonic ku-chip, i-bioimaging ku-chip, ukuzwa kwe-biochemical, kanye nokucutshungulwa kolwazi lwe-quantum photon, badinga ukufeza umphumela we-laser ekunqumeni ubude be-wavelength kanye nokunemba kwe-band okulinganiselwe kakhulu. Kodwa-ke, kuseyinselele ukukhiqiza ama-laser e-microdisk kanye ne-nanodisk alobu bude be-wavelength obunembile ngezinga elikhulu. Izinqubo zamanje zokwenza i-nano zethula ukungahleleki kobubanzi be-disc, okwenza kube nzima ukuthola ubude be-wavelength obuhleliwe ekucutshungulweni nasekukhiqizweni kwe-laser mass. Manje, ithimba labacwaningi abavela eHarvard Medical School kanye naseMassachusetts General Hospital's Wellman Center forImithi ye-Optoelectronicisungule indlela entsha yokuqopha i-optochemical (PEC) esiza ekulungiseni ngokunembile ubude be-laser ye-microdisk laser ngokunemba kwe-subnanometer. Lo msebenzi ushicilelwe kumagazini i-Advanced Photonics.
Ukuqopha nge-photochemical
Ngokusho kwemibiko, indlela entsha yethimba ivumela ukukhiqizwa kwama-laser e-micro-disk kanye nama-laser e-nanodisk arrays anama-wavelength aqondile, anqunyiwe kusengaphambili. Isihluthulelo salokhu kuphumelela ukusetshenziswa kwe-PEC etching, enikeza indlela ephumelelayo nengalinganiswayo yokulungisa ubude be-wavelength be-laser ye-microdisc. Emiphumeleni engenhla, ithimba lithole ngempumelelo ama-microdisk e-indium Gallium arsenide phosphating ambozwe nge-silica esakhiweni sekholomu ye-indium phosphide. Base belungisa ubude be-wavelength be-laser balama-microdisk ngokunembile ngenani elinqunyiwe ngokwenza i-photochemical etching kusisombululo esincishisiwe se-sulfuric acid.
Baphinde bahlola izindlela kanye nokuguquguquka kwezithombe ezithile ze-photochemical (PEC). Ekugcineni, badlulisela i-microdisk array elungiswe ubude bayo ku-polydimethylsiloxane substrate ukuze bakhiqize izinhlayiya ze-laser ezizimele, ezihlukanisiwe ezinama-laser wavelength ahlukene. I-microdisk ephumelayo ikhombisa i-bandwidth ye-ultra-wideband yokukhishwa kwe-laser, kanyei-laserkukholamu engaphansi kuka-0.6 nm kanye nenhlayiya ehlukanisiwe engaphansi kuka-1.5 nm.
Ukuvula umnyango wezinhlelo zokusebenza zezokwelapha
Lo mphumela uvula umnyango wezinhlelo eziningi ezintsha ze-nanophotonics kanye nezinhlelo zokusebenza ze-biomedical. Isibonelo, ama-laser e-microdisk azimele angasebenza njengama-barcode e-physico-optical amasampula ebhayoloji angafani, okuvumela ukulebula izinhlobo ezithile zamaseli kanye nokuqondiswa kwama-molecule athile ekuhlaziyweni kwe-multiplex. Ukulebula uhlobo oluthile lweseli okwamanje kwenziwa kusetshenziswa ama-biomarker avamile, njenge-organic fluorophores, ama-quantum dots, kanye nama-fluorescent beads, anobubanzi bokukhishwa okubanzi. Ngakho-ke, izinhlobo ezimbalwa zamaseli ezithile kuphela ezingalebula ngesikhathi esisodwa. Ngokuphambene nalokho, ukukhishwa kokukhanya kwe-ultra-narrow band kwe-microdisk laser kuzokwazi ukuhlonza izinhlobo eziningi zamaseli ngesikhathi esisodwa.
Ithimba lihlole futhi labonisa ngempumelelo izinhlayiya ze-laser ze-microdisk ezilungiswe kahle njenge-biomarkers, bezisebenzisa ukulebula amaseli e-epithelial ajwayelekile ebele akhuliswe i-MCF10A. Ngokukhishwa kwawo kwe-ultra-wideband, lawa ma-laser angashintsha i-biosensing, esebenzisa amasu e-biomedical kanye ne-optical afakazelwe njenge-cytodynamic imaging, i-flow cytometry, kanye nokuhlaziywa kwe-multi-omics. Ubuchwepheshe obusekelwe ekuqopheni kwe-PEC buphawula intuthuko enkulu kuma-laser e-microdisk. Ukusabalala kwendlela, kanye nokunemba kwayo kwe-subnanometer, kuvula amathuba amasha okusetshenziswa okuningi kwama-laser kumadivayisi e-nanophotonics kanye ne-biomedical, kanye nama-barcode emiphakathini ethile yamaseli kanye nama-molecule okuhlaziya.
Isikhathi sokuthunyelwe: Jan-29-2024